Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom
نویسندگان
چکیده
منابع مشابه
Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom
BACKGROUND Snake venom is a potentially lethal and complex mixture of hundreds of functionally diverse proteins that are difficult to purify and hence difficult to characterize. These difficulties have inhibited the development of toxin-targeted therapy, and conventional antivenom is still generated from the sera of horses or sheep immunized with whole venom. Although life-saving, antivenoms co...
متن کاملCorrection: Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom
1524 October 2008 | Volume 5 | Issue 10 | e209 Correction: Bioinformatics and Multiepitope DNA Immunization to Design Rational Snake Antivenom Simon C. Wagstaff, Gavin D. Laing, R. David G. Theakston, Christina Papaspyridis, Robert A. Harrison Correction for: Wagstaff SC, Laing GD, Theakston RDG, Papaspyridis C, Harrison RA (2006) Bioinformatics and multiepitope DNA immunization to design ratio...
متن کاملNew techniques in antivenom production and active immunization against snake venoms.
Standard methods of commercial antivenom production are costly both in terms of animals, their maintenance, the use of large amounts of expensive venoms and man-hours. The basic technology, which involves the hyperimmunization of horses, bleeding and subsequent purification of the plasma immunoglobulin G (IgG) using salt precipitation and pepsin digestion, has not advanced significantly for man...
متن کاملAdverse reactions to snake antivenom, and their prevention and treatment.
Antivenom is the mainstay of treatment of snakebite envenoming. However, adverse reactions to snake antivenom that is available are common in many parts of the world where snakebite is prevalent. Both acute (anaphylactic or pyrogenic) and delayed (serum sickness type) reactions occur. Acute reactions are usually mild but severe systemic anaphylaxis may develop, often within an hour or so of exp...
متن کاملProgress and improvement of the manufacturing process of snake antivenom
Antivenoms have been used successfully for more than a century and up to now constitute the only effective treatment for snakebites .The production of antivenin started long time ago when the calmette was prepared the antivenom in 1894.The method currently used to prepare antivenom by most of the manufacturers are originated from the method of Pope which was develop in 1938. Several new approac...
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ژورنال
عنوان ژورنال: PLoS Medicine
سال: 2006
ISSN: 1549-1676
DOI: 10.1371/journal.pmed.0030184